Effects of clonidine on release of substance P from rat spinal cord
- VernacularTitle:可乐定对脊髓P物质释放的影响
- Author:
Hongbing WANG
;
Shiao JIN
;
Zhongxin REN
- Publication Type:Journal Article
- Keywords:
Clonidine Analgesia Spinal cord Substance P
- From:
Chinese Journal of Anesthesiology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To study effects of clonidine on release of substance P from rat spinal cord for analysing the spinal sites of its pain relief, Method: Twenty rats were randomly divided into two groups: clonidine group and control group, clonidine 40?g or normal saline was injected intraperitoneally. Immunohistochemica] PAP technique was used to measure substance P in slices of rat spinal cord. Result: The optical density(OD) of immunoreaction of substance P in medial-lateral part of spinal dorsal horn and spinal Lissauer's tract was increased significantly in clonidine group com pared with that of control group (P
