Effects of aprotinin on circulation endothelial cells and endothelin during open heart surgery
- VernacularTitle:抑肽酶在休外循环中对内皮素和循环内皮细胞的影响
- Author:
Cun LONG
;
Jingwen LI
;
Tianyu YANG
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass Endothelium, vascuiar Cells Endothelins Aprotinin
- From:
Chinese Journal of Anesthesiology
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the changes of circulating endothelial cells (CEC) and endothelin(ET) and the effect of aprotinin on them during open heart surgery. Method:Twenty patients undergoing valve replacement were divided into two groups,control group(n=10) in which and protinin group (n=10), 4000000 unit aprotinin were given during cardiopulmonary bypass (CPB), Blood samples were collected before operation,pre-CPB,15,30 and 60 minute following CPB and 1st, 3rd, 5th day after operation. Result: As compared to pre-CPB in control group,CEC and ET levels increased during CPB and returned the normal after operation. In aprotinin group,the tendency of change was same,but CEC and ET levels were higher in control group than in aprotinin group during CPB. Conclusion:There are endothelial ceils damaging and ET significant increasing during CPB,while aprotinin can ameliorate this situation.
