Bronchiolitis obliterans in renal transplant patients.
10.3348/jkrs.1992.28.2.191
- Author:
Myung Hee CHUNG
;
Seog Hee PARK
;
Kyung Sub SHINN
;
Yong Whee BAHK
;
Kyu Young LEE
- Publication Type:Original Article
- MeSH:
Arthritis, Rheumatoid;
Biopsy;
Bone Marrow Transplantation;
Bronchioles;
Bronchiolitis Obliterans*;
Bronchiolitis*;
Connective Tissue;
Drug-Related Side Effects and Adverse Reactions;
Fibrosis;
Glass;
Graft vs Host Disease;
Humans;
Hyperplasia;
Kidney Transplantation;
Lung;
Macrophages;
Pneumocytes;
Radiography, Thoracic
- From:Journal of the Korean Radiological Society
1992;28(2):191-196
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Bronchiolitis obliterans is a distinct pathologic entity, characterized by the accumulation of pigmented macrophages within respiratory bronchioles and adjacent to air spaces, and thickening of the peribronchial interstitium. It has been reported to be associated with viral infection, drug, toxic fume, bone marrow transplantation, and connective tissue disorders such as rheumatoid arthritis. The etiology of bronchiolitis obliterans in the post-renal transplantation state is not yet clear, although several possibilities such as drug toxicity, graft-versus-host disease or postinfectious condition have been postulated. We presented three patient who had bronchiolitis obliterans, as a complication following renal transplantation. Chest radiograph showed bilateral perihilar reticular infiltration or ground glass appearances that progressed to either diffuse alveolar consolidations or solitary nodule. The main finding in each lung biopsy was the presence of macrophages within respiratory bronchioles as well as in the neighboring alveolar ducts and alveoli. Alveolar septa in these areas often showed nonspecific thickening by fibrosis, mild chronic inflammatory cell infiltrate, and hyperplasia of alveolar lining cells and type II pneumocytes.
