Effects of LPS, IL-1? and IFN-? on morphological and functional changes of cultured human aortic endothelial cells
- VernacularTitle:脂多糖和某些致炎细胞因子对培养人内皮细胞形态与功能的影响
- Author:
Hailan TANG
;
Baishuang LIN
- Publication Type:Journal Article
- Keywords:
Endothelium ? Nitric oxide ? Lipopolysaccharides
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The significant changes in morphology and nitric oxide synthase (NOS) activity in cultured human aortic endothelial cells (HAEC) were observed when these cells were exposed to LPS, IL-1? and IFN-?. NOS activity increased at 6h of treatment, the time point that HAEC began to change and elongate. The cell shape became fibroblast like and the length to width ratio of the cells increased 2 times of that of the control at 20h treatment, the time point that NOS activity returned to control level.
