Effects of NO and NO synthetase inhibitor on endogenous endothelin secretion in acute renal failure in rats
- VernacularTitle:NO及NO合成酶抑制剂对急性肾衰大鼠内源性内皮素分泌的影响
- Author:
Xiaohong XIA
;
Yuxue SHEN
;
Jixin SUN
;
Jicai SHI
- Publication Type:Journal Article
- Keywords:
Nitric oxide? Arginine ? Kidney failure, acute
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of L-arginine (L-Arg), the physiological NO precureor and NO synthetase inhibitor NG-nitro-L-arginine (L-NNA) on endogenous endothelin (ET) secretion and renal function were observed in a model of glycerol-induced acute renal failure (ARF) in rat. It was found that endogenous ET secretion was significantly increased, while serum NO was markedly decreased in ARF rats. The administration of L-NNA to the ARF rats induced significant increases in plasma ET and positive immunoreactive particles of ET in renal tubular epithelial cells(EP cells), and the impairment of renal function was exaggerated. L-Arg might effectively decrease the level of plasma ET and the positive immunoreactive particles of ET in renal tubular EP cells, suggesting the improvement of the renal function. It is suggested that the ability of NO in improving renal function may relatedto the inhibition of endogenous ET secretion in glycerol-induced ARF rats.
