Changes in extracellular adenosine in the rabbit striatum and cerebral cortex during incomplete cerebral ischemia
- VernacularTitle:不完全脑缺血期间家兔尾核与大脑皮质区细胞外腺苷的变化
- Author:
Yanzhi HOU
;
Gouwei LU
- Publication Type:Journal Article
- Keywords:
Ganglia, sympathetic ? Cerebral ischemia ? Cerebral cortex ? Caudate nucle-us ?Adenosine ? Dialysis
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Microdialysis probes were implanted into the rabbit cerebral cortex and caudate nucleus followed by perfusion with Ringer solution at a flow rate of 3.0?l/min. Cerebral ischemia was induced by electrical stimulation of the unilateral superior cervical ganglion for 1h. Dialysate samples were analyzed by high performance liquid chromatography (HPLC). Following ischemia, extracelluar (EC) contents of adenosine (Ado) and its metabolites were significantly increased upto 6 ～ lOfold(Ado), 5 ～ 6fold(Inosine, Ino) and 2 ～ 3fold(Hypoxanthine, Hyp) in both the cerebral cortex and caudate nucleus(P
