Increased lymphocyte interleukin (IL -2) activity in guinea pigs with ovalbumin (OVA) - induced bronchial asthma
- VernacularTitle:卵蛋白致敏哮喘豚鼠淋巴细胞白介素-2活性增强及其机制
- Author:
Hailu HUANG
;
Nanshan ZHONG
;
Zhaohui LIU
;
Pixin RAN
- Publication Type:Journal Article
- Keywords:
Asthma ?Lymphocytes ?Interleukin ?2 ?Guinea pigs
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Airway inflammation in atopic asthma is characterized by T -cell activation, leading to the release of certain cytokines. In this study the IL-2 activity and IL-2 mRNA express in the lymphocytes in guinea pigs with OVA -induced bronchial asthma was measured. It was found that eosinophils and lymphocytes were predominant cells in the peritoneal lavage fluid and bronchoalveolar lavage fluid (BALF) in asthmatic guinea pigs. Compared with contol group, the IL-2 activities in lymphocytes from the BALF (22.56? 2.44 ng/ml vs 14.23 ?4.71ng/ml, P
