The role of tumor necrosis factor alpha in the pathogenesis of immunologically mediated aplastic anemia in mice
- VernacularTitle:肿瘤坏死因子在免疫介导的再障小鼠发病中作用的研究
- Author:
Dongsheng YAO
- Publication Type:Journal Article
- Keywords:
Anemia, aplastic ? Tumor necrosis factor? Gene expression regulation
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The plasma levels of TNF alpha was determined dynamically using TNF ELISA; and TNF mRNA in spleen cells from varied groups was determined using Northern Blot. The results showed that: (1) Elevated levels of TNF-alpha in plasma from mice of immunologically- mediated aplastic anemia. (2) Induced production of TNF from spleen cells were much lower in exprimental groups than that in normal control group. (3) Decreased TNF-? gene expression present in spleen cell in AA group compared with normal control group.
