Influence of aspirin on nerve injury of experimental cerebral ischemia in rabbits
- VernacularTitle:阿司匹林对实验性兔脑缺血神经损害的影响
- Author:
Shixiang LIU
;
Jingbian HOU
;
Qingzhou YANG
;
Jialin ZHANG
;
Lichun HUANG
- Publication Type:Journal Article
- Keywords:
Aspirin ? Cerebral ischemia ? Blood platelets ? Free radicals ? Calcium ? Rabbits
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Platelet play an important role in cerebral ischemial nerve injury. Aspirin (ASA) had been used to treat and prevent stroke in clinic. 30 rabbits were randomly divided into A, B and C groups. In group A ASA was given orally at a daily dosage of 15 mg/kg per rabbit for 5 days before cerebral ischemia; group B cerebral ischemia without giving ASA, and group C was normal rabbits as controls. The cerebral ischemial model was produced by occluding bilateral carotid arteries and bleeding from femoral artery. The results indicated that there was an obvious decrease of PAgT and TXA_2 and had no significance changes in free radicals increasing and Ca~(2+) rising from cerebral tissue in group A. The cerebral edema of group A was less severe than group B. It seemed that ASA had a protective effect on the nerve injury of cerebral ischemia. The derangement of ASA, platelet, free radicals and calcium ions interrelation and their significance on the nerve injury should be further studied.
