Study of Interleukin-1 Receptor Antagonist Gene Polymorphism in Alopecia Areata
- VernacularTitle:斑秃患者白介素1受体拮抗剂基因多态性研究
- Author:
Junming ZHANG
;
Yuzhu TANG
;
Tonghua XU
- Publication Type:Journal Article
- Keywords:
Alopecia;
areata;
Receptors;
interleukin-1;
Gene
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Alopeeia areata (AA) has been well recognized with familial tendencies, but the genetic basis of this clinical observation remains unknown. The cytokine interleukin-1 receptor antagonist (ILlra) is a potent anti-inflammatory protein that can prevent immune-mediated inflammatory response in the skin. We characterized a polymorphism within the gene for this cytokine ILlra in this study and tested the gene as a possible marker in patients with alopecia areata. We have determined allele frequencies of the polymorphic cytokine genes in a control population and a group of 72 patients with alopecia areata. The frequency of allele 2 of interleukin-1 receptor antagonist in patients with AA was significantly higher than that of control group. It suggests that interleukin-1 receptor antagonist gene may be a candidate gene or severity factor for alopecia areata.
