STUDY ON DISTRIBUTION OF ALPRAZOLAM IN EXPERIMENTAL POISONED RABBITS
- VernacularTitle:阿普唑仑在家兔体内的分布研究
- Author:
Keming YUN
;
Guiming LI
- Publication Type:Journal Article
- Keywords:
Alprazolam poisoning TLC
- From:
Chinese Journal of Forensic Medicine
1988;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
A qualitative and quantitative analysis of alprazolam in biological samples by TLC scan is described in this paper. The distribution of alprazolam in poisoned rabbits was studied. It is showed that 4 hours after a dose of 21mg/kg, the concentration of the drug in liver, spleen, kidney; lungs, heart,brain, blood,bile and urine of poisoned rabbits were 19. 6 ? 6. 1, 3.31?0. 5, 3. 5? 0. 3, 0. 4? 0.1, 0. 4 ?0. 1, 1. 6 ? 1. 8, 4. 0 ? 1. 3, 20. 4 ? 8.0 and 8. 6 ? 2. 4ug/ml. Alprazolam is not well-distributed in poisoned rabbits. Blood, bile, urine and liver are better samples for analysis of alprazolam poisoning victim.
