Protective effect of phospholipase A_2 inhibitor on vital organs injury from intestinal ischemia-reperfusion
- VernacularTitle:磷脂酶A_2抑制剂对肠缺血再灌注致多器官功能损伤的保护作用
- Author:
Gang ZHAO
;
Huifang XU
;
Wei JIANG
- Publication Type:Journal Article
- Keywords:
Reperfusion injury;
Intestine;
PhospholipaseA_2;
Multiple organ failure
- From:
Chinese Journal of Anesthesiology
1996;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Phospholipase A_2 (PLA_2) inhibitor quinacrine was used to explore protective effect on multiple organ dysfunction (MOD) caused by intestinal ischemia-reperfusion (I/R) in rats. Gut I/R caused the increase of gut PLA_2 activity and induced endotoxemia and bacteriemia. Pretreatment with intravenous quinacrine 10mg?kg~(-1) attenuated bacteria and endotoxin translocation,markedly lowered the levels of thromboxane A_2 and prostacyclin I_2 in blood,and provided protection from the development of vital organs dysfunction. As a result,the survival rate in pretreatment group increased by 25%. The results demonstrate that gut I/R promotes gut barrier failure,then contributes to the development of MOD by allowing bacteria or endotoxin reaching the circulation. PLA_2 and PLA_2-dependent lipid mediators play an important role in the development of gut I/R injury and MOD. Intravenous quinacrine has protection against MOD resulting from gut I/R.
