The effects of fructose-1, 6-diphosphate after cerebral ischemia and reperfusionin in rabbits
- VernacularTitle:1,6-二磷酸果糖对兔脑缺血再灌注损伤的保护效应
- Author:
Shan ZHANG
;
Ruibin CAO
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia-reperfusion injury Fructose-1,6-diphosphate
- From:
Chinese Journal of Anesthesiology
1996;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Eighteen adult rabbits were randomly divided into three groups: normal, control and experimental group. The model of global cerebral ischemia was produced by four-vessel occulsion. The cerebral temporal cortex samples were collected to determine volume of the water, LPO and Ca~(2+) concentration,SOD activity,and pathologic examinations of the cortex were made by optical and electronic microscope. The results showed that fructose-1, 6-diphosphate (FDP) reduced the water content and intracellular Ca~(2+)level, restrained the LPO production, enhanced the SOD activity of the brain. It is concluded that FDP protects cerebral biological membrane to a certain degree from ischemia and reperfusion injury.
