Effects of sodium oxybate on pharmacodynamics of ketamine in animals
- VernacularTitle:羟丁酸钠对氯胺酮药效学的影响
- Author:
Tijun DAI
;
Miao YE
;
Ying FU
- Publication Type:Journal Article
- Keywords:
Sodium oxybate Ketamine Interaction
- From:
Chinese Journal of Anesthesiology
1996;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
The interaction between sodium oxybate and ketamine were studied in conscious animals. Sodium oxybate increased the LD_(50) of ketamine, increased the incidence of sleep caused by ke tamine and prolonged the sleep duration and potentiated analgesic action of ketamine. Sodium Oxybate didn't effect the respiratory and circulatory function in rabbits. The results showed sodium oxybate po tentiated the anesthetic action of ketamine and reduced the side effect of ketamine. So It is suggested that sodium oxybate has the anesthetic synergism with ketamine in animals.
