The effect of ketamine on the contents of the excitatory amino acid transmitters and calcium in rabbit brain tissue after rabbit cerebral ischemia and reperfusion
- VernacularTitle:氯胺酮对缺血再灌注脑组织兴奋性氨基酸递质及钙含量的影响
- Author:
Jiashun REN
;
Min BI
- Publication Type:Journal Article
- Keywords:
Ketamine Ischemia reperfusion Excitatory amino acid Transmitter Calcium
- From:
Chinese Journal of Anesthesiology
1996;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia models of rabbits were induced by four-artery obstruction method. The changes of excitatory amino acid (EAA) transmitters,brain-tissue calcium (TCa) and intramitochondria calcium (MCa) of the cerebral cortex were measured and the effects of ketamine were observed. The results revealed that 20 minutes after ischemia,the amoumts of the EAA transmitters (Glu and Asp) in brain tissues were decreased, and decreased further after reperfusion. But after 20 minutes ischemia,the levels of TCa and MCa were elevated and higher than that of ischemia and contral groups significantly after the reperfusion. Ketamine could increase the Glu and Asp contents and decrease the TCa and MCa levels during ischemia and reperfusion.
