The Influence of Insulin on Antagonistic Effects of Phentolamin and Tolasuline on Norepinephrine-induced Vasoconstriction
- VernacularTitle:胰岛素对酚妥拉明及妥拉苏林拮抗去甲肾上腺素作用的影响
- Author:
Feng WANG
;
Min LU
;
Xiaoli JI
;
Caiyi/ LU
- Publication Type:Journal Article
- Keywords:
insulin hypertension norepinephrine phentolamin tolasuline
- From:
China Pharmacy
1991;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The antagonistic effects of phentolamin(PL) and tolasuline(TS) on norepinephrine(NE)-induced vasoconstriction were investigated in vitro on aortic rings of normotensive and spontaneously hypertensive rats in Kreb-Henseilet solution containing 40?IU/ml insulin.The results showed that in the presence of high level insulin,the antagonistic actions of ?-receptor blocking agents,PL and TS,were markedly decreased.The pharmacodynamic parameters indicated that the affinity index and action intensity of PL and TS were significantly reduced in solution containing high level insulin.The experimental results showed that high concentration insulin could decrease the antagonistic effects of ?-receptor blocking agents on NE-induced vasoconstriction.
