Sodium Tonshinone Ⅱ_A sulfonat against myocardial reperfusion injury
- VernacularTitle:丹参酮防治心肌再灌注损伤的实验研究
- Author:
Jun TAO
;
Zhouqi WANG
;
Qiaoyi LIU
- Publication Type:Journal Article
- Keywords:
Myocardial reperfusion injury Oxygen-derived free radicals Sodium Tanshinone Ⅱ_A sulfonat
- From:
Chinese Journal of Anesthesiology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The experiment was done to explore the effect of sodium Tanshinone Ⅱ_A, sulfonat (STS) on myocardial reperfusion injury. Myocardial ischemia was induced with the occlusion of left anterior descending coronary artery lasting 30 minutes, and postischemic reperfusion persisted 30 minutes also. Fifty rabbits were randomly divided in to five groups: operative control group (group Ⅰ, n=10), myocardial ischemia group (group Ⅱ, n=10), myocardial ischemia and reperfusion group (group Ⅲ, n=10), receiving intravenous STS 5mg?kg~(_1) 5 mins before the reperfusion (group Ⅳ, n=10) and receiving intravenous STS 5mg?kg~(_1) 10 mins before the ischemia and 5 mins before the reperfusion respectively (group Ⅴ, n=10). As compared with those of group Ⅰ, the amount of myocardial malondialdehyde (MDA) increased significantly in group Ⅱ and Ⅲ (P0.05); the activity of myocardial superoxide dismutase (SOD) decreased in group Ⅲ(P0.05); the serum creatine kinase (CK) activity rose markedly in group Ⅱ, Ⅲ and Ⅳ (P0.05). In comparison with those of group Ⅲ, the amount of MDA reduced and activity of SOD increased in group Ⅳ and Ⅴ (P
