Relationship between onset and offset time of non-depolarizing neuromuscular blocking agents
- VernacularTitle:非去极化肌肉松弛药起效和消退速度间的关系
- Author:
Xinmin WU
- Publication Type:Journal Article
- Keywords:
Vecuronium Pancuronium Mivacuronium Doxacurium Biophase binding Onset time Offset time
- From:
Chinese Journal of Anesthesiology
1994;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
There is evidence that onset time and potency of the non-depolarizing neuromuscular blocking agents are related. The relationship between onset time and the rate of recovery has been less well studied. In this experiment, the myodynamie response of adductor pollicis to single electric stimulation of wrist ulnar nerve, served as the parameter of neuromuscular blockade, and with the isolated forearm technique being used, the onset and offset times of vecuronium, pancuronium, mivacuronium or doxacurium were recorded in four adult healthy volunteers respectively. The results indicated that there was a positive correlation between onset and offset times (r=0.958, P
