STUDY OF ALCOHOL PHARMACOKINETICS IN HUMAN BODY
- VernacularTitle:酒精在人体内的代谢动力学研究
- Author:
Jianghua LAI
;
Bingwei HU
- Publication Type:Journal Article
- Keywords:
Alcohol;
Pharmacokinetics;
Nonlinear elimination
- From:
Chinese Journal of Forensic Medicine
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Sixteen normal male volunteers were randomly divided into two groups and were asked to drink two doses of ethanol 0. 65g/kg and 0. 80g/kg alcoholic beverage seperately. Then the venous blood sample was collected at the different time. A ADH enzyme catalyzed method was used to determine the blood alcohol concentration (BAC). The experimental concentration-time (C-T) data was calcu-lated by the pharmacokinetics software,the result showed that the metabolism of alcohol confirmed with 1 -compartment nonlinear pharmacokinetics with first absorption model. According to this, a mathematic formula of alcoholic dynamics in human body was established. After the test of human ex-periment, the model was found suitable in the practice of forensic medicine.
