Effects of nifedipine on stress responses to tracheal intubation: a randomized placebo-controlled clinical study
- VernacularTitle:静脉注射硝苯地平预防气管插管副反应的临床研究
- Author:
Tiezheng ZHANG
;
Xiaojiang LIU
;
Kai ZHAO
- Publication Type:Journal Article
- Keywords:
Nifedipine Tracheal intubation Cardiovascular response Endocrine response
- From:
Chinese Journal of Anesthesiology
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to investigate the effects of nifedipine on stress responses to tracheal intubation. Thirty adult patients, ASA Ⅰ to Ⅱ, scheduled for elective surgery, were randomly assigned to receiving intravenous infusion of normal saline 30ml (group Ⅰ). fentanyl 5?g/kg (group Ⅱ) or nifedipine 40 ?g/kg(group Ⅲ), respectively. After intravenous thiopental, valium and atracurium. the tracheal intubation was performed. SP, DP, HR and RPP were determined before administration, immediately before and after intubation. 1, 3 and 5 min following intubation separately, and the venous blood samples were taken at correspondingly later 5 times to measure plasma concentrations of endotheline(EF), atrial natriuretic polypeptide (ANP), TXB_2 and 6-keto-PGF_1 ? by radioimmunoassay individually. Following intubation. MAP went up in group Ⅰ and transiently in group Ⅱ and Ⅲ, HR in creased by 36.6% and 33.3% in group Ⅰ and Ⅲ and remained stable in group Ⅱ, RPP rose in group Ⅰ and rept statistically unchanged in group Ⅱ and Ⅲ, ET level stayed constant in all three groups, levels of ANP and TXB_2 ascended in group Ⅰ, transiently in group Ⅱ and did not vary in group Ⅲ, 6-keto-PGF_1? level were raised in group Ⅱ, transiently in group Ⅲ and did not change in group Ⅰ, and TXB_2/6-keto-PGF_1? ratio(T/K) shoot up in group Ⅰ and reduced in group Ⅱ and Ⅲ. As compared with those in group Ⅰ, before intubation, ANP level increased in group Ⅱ and Ⅲ. 6-keto-PGF_1? level decreased and T/K rose in group Ⅲ; after intubation, levels of ANP and 6-keto-PGF_1 ? went up in group F, transiently in group Ⅲ, and TXB_2 and T/K values went down in group Ⅱ and Ⅲ. It is suggested that prophylactic intravenous nifedipine may effectively depress the cardiovascular and hormone responses to tracheal intubation, but can not take complete place of fentanyl for this procedure.
