Dynamics of interleukin-6 and tumor necrosis factor alpha in patients with severe multiple trauma and their relationships to multiple system organ failure
- VernacularTitle:重度多发性创伤患者血清白介素-6及肿瘤坏死因子与多器官衰竭的关系
- Author:
Yuke TIAN
;
Ailin LUO
;
Shiao JIN
- Publication Type:Journal Article
- Keywords:
Mutiple system organ failure Severe multiple trauma Interleukin-6 Tumor necrosis factor alpha
- From:
Chinese Journal of Anesthesiology
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to evaluate the post-traumatic changes of serum levels of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF_?) and their relationship to the occurance of multiple system organ failure (MSOF), 80 adult patients with severe multiple trauma(SMT), injury severity score(ISS) 32?14. served as the tested subjects. of which 50 cases received operations and the other did not. Thirty adult patient, scheduled for elective abdominal surgery, were randomly chosen as trauma control, and 20 healthy blood donors acted as normal control. The venous blood samples were taken on that day of injury, 3, 10 and 20 days post-traumatically, and immediately before dis charge. to measure serum concentrations of IL-6 by immunocytochemistry method and TNF_? by enzymo-immunoassay, respectively. The diagnosis of post-traumatic MSOF was made according to Baue's criteria. As compared with normal control levels, the concentrations of IL-6 and TFN_?, increased significantly in patients with SMT(P0.05). In comparison correspondingly with those of trauma control, the levels of IL-6 and TFN_? were elevated markedly (P
