The Expression of c-erbB-1 and c-erbB-2 Oncoproteins in Basal Cell Carcinoma and Squamous Cell Carcinoma of Skin
- VernacularTitle:c-erbB-1及c-erbB-2癌基因蛋白在皮肤基底细胞癌与鳞状细胞癌中的表达
- Author:
Baojun LIU
;
Haitao ZHANG
;
Suqin LI
- Publication Type:Journal Article
- Keywords:
Carcinoma;
basal cell;
Carcinoma;
squamous cell;
Oncogene
- From:
Chinese Journal of Dermatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The expression of c-erbB-1 and c-erbB-2 oncoproteins were investigated by immunohistochemical technique using monoclonal antibodies to c-erbB-1 and c-erbB-2 oncoproteins in 43 cases of hasal cell carcinoma (BCC) and 26 cases of squamous cell carcinoma (SCC). The results showed that: ① The expression of c-erbB-1 oncoprotein in BCC increased; the expression of c-erbB-2 oncoprotein in BCC reduced significantly, and lost in 16 cases (16/43). ② The intensities of c-erbB-1 and c-erbB-2 oncoprorein expression had negative and positive correlations to the degrees of SCC differentiation respectively. It is suggested that the abnormal expression of c-erbB-1 and c-erbB-2 oncoprotein in BCC and SCC may play a role in the development of skin tumors.
