Preliminary Study on the Expression of C-myc Protooncogene in SLE Patients
- VernacularTitle:系统性红斑狼疮患者外周血单一核细胞C-myc原癌基因的表达
- Author:
Bin YANG
;
Qiliang ZHANG
;
Weijun CAI
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic C-myc protooncogene
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
By means of cell hybridization in situ with digoxigenin labeled probe, we detected the expression of C-myc protooncogene in peripheral blood mononuclear cells from 31 SLE patients and 10 healthy persons. The results showed that the level of C-myc mRNA in SLE patients was significantly higher than that in normal controls, and the increased level correlated with disease activity. There was also a positive correlation between C-myc mRNA and serum levels of ANA, anti-dsDNA, IgG, C3. Our study indicates that C-myc gene is important for the pathogenesis of SLE.
