Related Antigens of Skin Basement Membrane Zone in Bullous Systemic Lupus Erythematosus
- VernacularTitle:大疱性系统性红斑狼疮的皮肤基底膜带相关抗原
- Author:
Xuejun ZHANG
;
Mengwu WENG
;
Shouyi SHI
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus;
systemic Basilar membrane;
Antigen
- From:
Chinese Journal of Dermatology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Using immunoblotting analysis and salt-split skin indirect immunofluorescence, we studied sera from 5 patients with bullous systemic lupus erythematosus (BSLE) and 55 control subjects,including 20 cases of SLE, 20 cases of bullous pemphigoid (BP),5 cases of epidermolysis bullosa acquisita (EBA) and 10 normal volunteers. The results showed that the sera from 3 of 5 BSLE patients combined with dermal side of saltsplit skin and 290 000 antigen of dermal extracts in human skin. Sera from 2 BSLE patients which reacted with 290 000 antigen also combined with 165 000 antigen of epidermal extracts. Sera from SLE patients did not combined with both 290 000 and 165 000 antigens. The results suggest that there are EBA antibody and BP antibody in BSLE. We consider that EBA antigen and BP antigen may be the related antigens of skin basement membrane zone in BSLE.
