Regulations of Human Tumor Necrosis Factor and Recombinant Human Interferon-? on activity of Human Polymorphonuclear Neutrophils against Candida albicans
- VernacularTitle:肿瘤坏死因子和?干扰素对调节中性粒细胞抗白念珠菌活性的研究
- Author:
Wen JIANG
;
Yinling CHEN
;
Liyi ZHOU
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor Interferon type II;
Neutrophils;
Candida albicans
- From:
Chinese Journal of Dermatology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
This paper studies tile regulation of cytokines such as human tumor necrosis(Hu-TNF) and recombinant human interferon - (rHu -IFN - ) on activity of human polymorphonuclear neutrophils (PMN) against Candida albicans by determing numbers of colony - forming unit of Candida albicans. We detected that Hu - TNF and rHu IFN st did not interfere directly with fungal growth. These two cytokines enhanced PMN to inhibit Candida albicans growth. When preincubating PMN with Hu --TNF and rHu-IFN -togather, the activity of PMN against Candidaalbicans was synergically enhanced. The degree of enhancement of the activity of PMN againstCandida albicans was highly dependent on these two cytokines - PMN preincubation time. Thus,Hu -- TNF and rHu -- IFN -- have the ability to activate PMN, and the synergistic action of thetwo cytokines may prove clinically effective for increasing the ability of immuncompromised hosts against opportunistic fungal infectons.
