Effect of salvia miltiorrkiza and its effective composition on hypoxic pulmonary vaoconstriction in guinea pig.
- VernacularTitle:丹参及其有效成份对低氧性肺血管收缩作用研究
- Author:
Lianhua CHEN
;
Changsi XIAO
;
Qinyan GONG
- Publication Type:Journal Article
- Keywords:
Salvia;
miltiorrhiza;
Hypoxia;
Pulmonary;
Vasoconstriction
- From:
Chinese Journal of Anesthesiology
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The experiment was designed to investigate the effect of salvia miltiorrhiza (Danshen ) and its effective composition, phenyl lactic acid (Danshensu )on the hypoxic pulmonary vasoconstriction (HPV). Acute hypoxia was induced by replacing mixed gas 95%O2+ 5 %CO2 with 95%N2 + 5 %CO2. Hypoxic pulmonary vasoconstriction was diminished by injectic Danshen, Injectic Danshen compound and Danshensu with concentration dependently. Tile effect of Danshensu was the most,and Injectic Danshen Co was second by comparison. The results suggested that Danshen can antagonist HPV which was mainly produced by Danshensu, one of the effective composition of Danshen,and that more potent inhibitory action on HPV was by Injectio Danshen compound compared with Injectio Danshen,and this may be related to the addition of Dalbergia odorifera , the other composition of Injectic Danshen compound.
