Effect of hypoxia on isolated pig pulimonary artery rings with or without endothelium
- VernacularTitle:血管内皮在猪离体肺内动脉缺氧性收缩反应中的作用及机制
- Author:
Zhi MING
;
Dixun WANG
- Publication Type:Journal Article
- Keywords:
Pulmonary Artery;
Hypoxia;
Endothelium
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxic vasoconstriction was studied in isolated rings of pig intrapulmonary(PA) with or without endothelium. Arterial rings were suspended in modified Krebs' bic-arbonate solution for isometric recording. Hypoxia was induced by changing the bubblinggas mixture in the chamber from, 95% O_2-5%CO_2 to 95%N_2-5%CO_2. When PA ringswere prestimulated with phenylephrine (PE, 2?10~(-6) mol/L), hypoxia could induce contrac-ctions in PA (0.86?0.09g, n=12). Removal of the endothelium decreased the hypoxicontractions of PA significantly (tension increment 0.11?0.03g, n=12, P
