Erythrocyte membrane Na-pumping K~+-pNPPase activity and red cell deformability in diabetes mellitus
- VernacularTitle:糖尿病红细胞膜钠泵K~(+)-pNPPase活性与红细胞变形能力的关系
- Author:
Hauzan WANG
;
Hongxin QIU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Non-insulin-dependent;
Erythrocyte membrane
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The activity of erythrocyte membrane Na-pumping K~+-activated pera-nitro-phenylphosphatase (K~+-pNPPase) and red cell deformability (RCD) were stndied in 50adult patients with non-insulin-dependent diabetes mellitus (NIDDM). RCD was expressedas red blood cell filtration index (RBC-IF). In comparison with the healthy subject, theactivity of erythrocyte membrane Na-pumping K~+-pNPPase was significantly decreased,and RBC-IF was significantly increased. The above-mentioned changes were more severein NIDDM with retinopathy than those without. There was a very close negative corre-lation between Na-pumping K~+-pNPPase and RBC-IF. These results indicated that thedecrease of erythrocyte membrane Na-pumping K~+-pNPPase activity might be an importantfactor fot the decrease of RCD.
