Protective effect of Cordyceps Sinensis, Epimedium and Astragalus Membranaccus on gentamycin induced nephrotoxicity in rat
- VernacularTitle:淫羊藿、虫草菌丝、黄芪防治庆大霉素所致急性肾损害的实验研究
- Author:
Xiangmei CHEN
;
Jin TIAN
- Publication Type:Journal Article
- Keywords:
Gentamycins;
Kidney;
Na~+-K~+-ATPase adenosine triphosphatase
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Animal model of aged rat nephrotoxicity was induced by i. p. administrationof gentamycin in a dose of 140mg/kg/day. Part of those rats were treated with CordycepsSinensis(CS), Epimedium(Ep) and Astragalus Membranaccus (AM) in form of decoc-tion per Os and others seryed as control. The results were summarized as. 1. The nephro-toxicity of gentamycin was aggrevated with age. CS, Ep and AM are effective drugs inpreventing the tdeular damage caused by gentamycin in rats. The pathological changes ofrenal tuoules of the rat groups which treated with CS, Ep and AM were less severe thanthat of the control. 2. CS, Ep and AM could prevent the decline of renal cortical Na~+-K~+-ATPase activity of aged rat induced by gentamycin.
