The effect of ischemia and reperfusion on energy transductional function of rat heart mitochondria
- VernacularTitle:缺血/再灌注对大鼠心肌线粒体电子传递与质子泵出偶联的影响
- Author:
Hua ZHANG
;
Xuanmao JIAO
- Publication Type:Journal Article
- Keywords:
Ischmia;
Perfusion;
Mitochondria;
Heart;
Energy metabolism;
Oxidative phosphorylation
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia and reperfusion of rat hearts were produced by Langendorff per-fusion technique. The energy tranduction of the mitochondria isolated from the rat heartswas studied. The initial rate of proton ejection and eldectron transfering were measured.There was no significant difference of H~+/2_e ratio between the ischemic group and thecontrol group which was reduced only in the reperfusion group. The longer was the is-chemic period before reperfuaion, the smaller would be the H~+/2_e ratio. The lowering ofH~+/2_e ratio occurred earlier than that of the ADP/O ratio. RCR and ADP/O in shortperiod ischcmia group and reperfusion group were both much higher than that of the con-trol group.
