The effect of the calcium-channel-blocking agent on the febrile response induced by ET
- VernacularTitle:钙通道阻滞剂对内毒素性发热的抑制作用
- Author:
Chaofeng HU
;
Suimei ZHANG
- Publication Type:Journal Article
- Keywords:
Fever;
Endotoxin;
Prostaglandins E;
Adenosine cyclic monophospate
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
This experiment was carried out in 65 New Zealand rabbits. The resultsrevealed that the febrile response and increaed PGE_2 level in cerebrospipel fluid (CSF) were significantly reduced when the calcium-channel-blocking agent (verapamil) wasintravenously injected prior to ET. But, verapamil had no marked effect on the increasedcAMP level in csf during ET-induced fever. It was suggested that most likely this anti-pyretic action was due to the effect on biosynthesis of PGE in hypothalamus, while,cAMP might not be involved in the mechanism of this antipyretic action.
