Effect of free radicals induced by electrolysis on endothelium derived relaxing factor in rabbit cerebral basilar artery
- VernacularTitle:电解产生氧自由基对兔脑基底动脉释放内皮细胞松弛因子的影响
- Author:
Dekun SONG
;
Jie HE
- Publication Type:Journal Article
- Keywords:
Free radicals;
Endothelium;
Basilar artery;
Rabbits
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of free radicals induced by electrolysis on endothelium derived relaxing factor (EDRF) was studied in the isolated rabbit basilar artery using bioassaytechnique. It was found that after the injury was made by the free radicals, the relaxa-tion of the artery rings induced by Ach was decreased markedly while the contractioninduced by NE was very much augmented. Meanwhile, in the basilar arteries MDA con-tent was increased and SOD activity was decreased. Pretreated the basilar artery with SOD,led to the recovery of decreased relaxation and attenuation of changes in MDA and SOD.These results suggested that during subarachnoid hemorrhage, the release of EDRF wasdecreased which was closely related to the free radicals injury of the basilar arteries.
