Changes of pulmonary ?_1-and ?-adrenergic receptors during endotoxin-induced acute lung injury in rats
- VernacularTitle:大鼠内毒素性肺损伤中肺?_1和?受体的变化
- Author:
Gengyun SUN
;
Baoling MAO
- Publication Type:Journal Article
- Keywords:
Lung;
Endotoxin;
Receptors,Adrenergic,Alpha 1;
Beta
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Changes of pulmonary ?_1-and ?-adrenergic receptor (?_1-AR and ?-AR)during endotoxin-induced acute lung injury in rates were oberved to find out the rela-tionship between them and the mechanism of change. Results showed that there was amarked decrease of B_max of both ?_1-AR and ?-AR by 35% and 43% respectively, dur-ing acute lung injury. The down regulation of ?-AR might be one of causes of acutelung injury while that of ?_1-AR seems to be a protective response. Active oxygen playedan important role in endotoxin-induced down regulation of AR in the rat lungs. The increa-sed level of norepinephrine and epinephrine was not the main factor that initiate the downregulation of AR. Intravenous injection of tumor necrosis factor (5?10~6U/kg ) exerts noiafluence on the changes of pulmonary AR in rats.
