Effects of dexamethasone on the change of PLA_2 activity in endotoxin-induced lung injury
- VernacularTitle:地塞米松对内毒素急性肺损伤磷脂酶A_2活性变化的影响
- Author:
Linying LIU
;
Bin SUN
- Publication Type:Journal Article
- Keywords:
Phospholipase A_2;
Dexamethasone;
Endotoxin;
Lung injury
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Sheep with chronic lung lymph fistula were used as model, lung injurywas induced with endotoxin, changes of pulmonary phospholipase A_2(PLA_2) activity wasmeasured and the effect of dexamethasone on PLA_2 activity was also observed. The resultsshowed that after endotoxin infusion PLA_2 activity, thromboxane B_2 (TXB_2) and 6-Keto- prostaglandin F_1? (6-Keto-PGF_1?) increased markedly (P
