The Effect of TMV Compound Fibrino lytic Agent on Experimental Thrombotic Stroke
- VernacularTitle:烙铁头蛇毒纤溶制剂对局部血栓形成脑卒中的保护作用
- Author:
Liang LU
- Publication Type:Journal Article
- Keywords:
Thrombotic stroke;
Fibrinolytic agent;
Snake venom
- From:
Journal of Kunming Medical University
1988;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of TMY compound fibrinolytic agent separated from T. muctosqua matus ven- om on acute thrombotic stroke of cat model has been studied. The animal model of acute thrombotic stroke was obtained by exposing MCA transorbitally and inserting a copper wire into it. Intracarotid small dose continuous infusion of thrombolytic agents were used in the treatment of thrombotic stroke. The urokinase treatment group was for the positive control group. MCA thrombotic formation and recanalization after thrombolytic agents infusion were detected by DSA. FIB and WBPA rate were tested before and after thrombolytic agents infusion to explore the fibrinolytic mechanism of these agents. One week altar thrombotic for- mation, all the animals were CT scanned to test the infarction volumes ad intracranial bleed- ing. In the saline group, there were no recanalization within 24 hours and a define region of cerebral infarction voiume (32?9.6%) wets detected at one week after thrombotic forma- tion, In both TMV group and urokinase group, diminution of infarction volume (26.1 ? 8.8, 26.5? 9.4% ) and increase of recanalization rates ( 5/ 6, 6/ 7) were produced. Furthermore in both fibrinolytic treatment groups, system fibrinogenolysis and inhibition of platelet aggregation were produced after fibrinolytic agents infusion.
