The effect of isobaric hypoxia with hypercapnia on the density of ? and ? adrenoceptors in rat lung
- VernacularTitle:高CO_2伴有常压缺氧对大鼠肺组织?和?_1肾上腺素能受体密度的影响
- Author:
Xiaofang WANG
;
Quanfu XUE
- Publication Type:Journal Article
- Keywords:
Anoxia;
Hypercapnia;
Receptor,adrenergic;
Hypertension,pulmonary
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Rats were kept in hypoxic chamber. Results showed that hypoxia led topulmonary hypertension and right ventricular hypertrophy, hypercapnia exasperated thishypertrophy but was not to hypertension. At the same time, lung ?_1-adrenoceptor all in-creased in hypoxia with or without hypercapnia groaps, ?-adrenoceptor increased after 1weekof hypoxia, and decreased after 1week and 2weeks of hypoxia with hypercapnia. These resultssuggested that the different type of adrenoceptors showed a different change after hypoxia.Results implied that the imbalance of adrenoceptor in lung might led to domination ofvaso-constriction caused by increased ?-adrenocepor, which might play the role in hypoxicpulmonary hypertension. The followed up increase of ?-adrenoceptor after 2weeks of hypoxiawith hypercapnia might be a compensative effect to eliminate exasperation of ventricular,hypertrophy.
