Elevated levels of substance P and prostaglandins in sheep during endotoxin induced lung injury
- VernacularTitle:绵羊内毒素肺损伤时P物质和前列腺素含量变化
- Author:
Jun WANG
;
Bin SUN
- Publication Type:Journal Article
- Keywords:
Substance P;
Endotoxin;
Lung injury;
Thromboxane B_2;
6-Keto-PGF_(1?)
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
A high dose E. Coli endotoxin was infused into unanesthetized sheep withchronic lung lymph fistula. The contents of substance P in plasma, lung lymph, lungparenchyma and also TXB_2 and 6-keto-PGF_1? were measured. The results showed that 120min after infusion substance P increased in plasma and lymph, but its content in paren-chyma decreased at 360 min after infusion. At 30 min after infusion, TXB_2 and 6-keto-PGF_1? levels in plasma showed a marked increase, but their peak values in lung lymphwere shown at 60 min after infusion, and the levels of TXB_2 were much higher than thatof 6--keto--PGF_1?
