Changes of calcium transport of rat myocardial mitochondria during septic shock
- VernacularTitle:败血症大鼠心肌线粒体钙转运能力的变化
- Author:
Linwang DONG
;
Chaoshu TANG
- Publication Type:Journal Article
- Keywords:
Shock,septic;
Myocardium;
Mitochondria,heart;
Calcium;
Rat
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
In oeder to investigate the pathogenetic role of mitochondria in the patho-genesis of intracellular calcium overload in septic rat. The present study observed the cal-cium content and calcium influx into myocardial mitochondria on the early and late sepsisof rat produced by cecal ligature and puncture. The results showed that mitochondrialcalcium contents increased markedly in both early (180%) and late (330%) sepsis. Thecalcium transport capacity of mitochondria in late sepsis decreased dramatically (uptakedecreased 34.6%, uptake velocity lowered 33.3%, p
