The effect of isobaric hypoxia on the density of subtypes of ? and ? adrenoceptors in rat lung
- VernacularTitle:常压缺氧性肺动脉高压大鼠肺组织肾上腺素能受体亚型数目的动态变化
- Author:
Xiaofang WANG
;
Quanfu XUE
- Publication Type:Journal Article
- Keywords:
Anoxia;
Receptor,adrenergic;
Hypertension,pulmonary;
Autoradiography
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Rats were kept in isobaric hypoxic chamber (O_2=10%)for ? , ? and 4 weeks(6h/day, 6days/week). The lung adrenoceptors were measured by radioligand bindingtechnique. Results showed that the ? adrenoceptor increased at 1st week of hypoxia and de-creased significantly at 2nd and 4th weeks of hypoxia. The change of ?_2 adrenoceptor wasconsistant with that of total ? adrenoceptor but the decrease was more significant. By con-trast, the ?_2 adrenoceptor increased significantly all the time. No change of Kd valuewas found in this study. The data indicated that the changes of adrenoceptors induced byhypoxia caused the domination of pulmonary vasoconstriction which may play a role inthe developement of hypoxic pulmonary hypertension.
