Antagonistic effects of ruthenium red on the biological activities of endotoxin
- VernacularTitle:钌红对内毒素多种生物活性的拮抗作用
- Author:
Liang YAN
;
Hailan TANG
- Publication Type:Journal Article
- Keywords:
Ruthenium red;
Endotoxins;
Limulus test
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The antagonistic effects of ruthenium red (RuR) on the biological activi-ties of endotoxin (ET) which included the limulus amebocytes lysate test, the local Shw-artzman reaction, decreasing the white blood cell counts, and increase of zinc in periphe-ral blood were observed. The destroyed meshes of endotoxin have been seen under electronmicroscope. The amino-groups of endotoxin increased markedly, which it was treated withRuR. These results indicated that the polycationic residues of RuR may be the effectiveunits of antiendotoxin activity.
