Correlative analysis of free amino acid changes in plasma and brain in hepatic encephalopathy of fulminant hepatic failure in rats
- VernacularTitle:暴发性肝损伤肝性脑病大鼠血浆及脑游离氨基酸变化的相关分析
- Author:
Xianming CHEN
;
Yuauchang ZHAO
- Publication Type:Journal Article
- Keywords:
Hepatic encephalopathy;
Amino acids;
Blood-brain barrier;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Changes of free amino acids in plasma and brain of rats with fulminanthepatic failure were measured with a Beckman 6300 amino acid analyzer.Results indicat-ed that as hepatic encephalopathy developed, concentrations of almost all amino acids inplasma and brain were increased.The levels of most amino acids in brain showed no cor-relation with their changes in the plasma.However,changes of concentrations of theseamino acids in brain that were related to the development of hepatic encephalopathy wereclosely correlated with their concentrations in plasma.Not any correlations between chan-ges of any amino acids in plasma and brain were found in normal control rats.Theseresults suggested that amino acid transport mechanisms appeared to be specific in the blo-cd-brain barrier during fulminant hepatic failure,a phenomenon that could contribute tothe neural disturbance of hepatic encephalopathy.
