The prophylactic effects of Tanshinone on experimental cerebral infarction in rats
- VernacularTitle:丹参酮对大鼠实验性脑梗塞的防治作用
- Author:
Jiandong LIU
;
Ruyu TANG
- Publication Type:Journal Article
- Keywords:
Dexamethasone;
Cerebral infarction;
Leukocytes;
Lipid peroxides;
Superoxide dismutase
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Twenty four hours after occluding of the middle cerebral artery in rats, thecirculating neutrophils were in activated state and the lipidperoxidation increased in ische-mic brain tissue. Tanshinone inhibited the chemoluminescence of the circulating neutrophilphagocytosis and decreased leukocyte infiltration in infarcted brain tissue. It alsodecreased lipoperoxide, malondialdehyde and increased SOD activity in ischemic cerebralregion. In addition, it reduced cerebral infarction size in the model. The correlationbetween inhibitory effects on leukocyte and reduction in ischemic cerebral damage wassignificant. Dexamethasone used as a positive control had similar effects on neutrophils andischemic cerebral injury. It was shown that the prophylactic effcts of Tanshinone oncerebral infarction might be mainly due to its inhibition on leukocyte function.
