The relation of hyperlipidemia, lipid peroxidation, anti-oxidative enzyme activity to atherosclerosis
- VernacularTitle:高脂血症、脂质过氧化、抗氧化酶活性与动脉粥样硬化的关系
- Author:
Yongcai LU
;
Shuhua WANG
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Lipid peroxide;
Superoxide dismutase;
Glutathione peroxidase;
Hyperlipidemia
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerotic model of rabbit was established by feeding heavy dosage ofcholesterol for 60 days and then withdrew it for 30 days. The relation between cholesterolcontent, lipld peroxide (LPO), activity of antioxidative enzyme and the evolution of ath-erosclerotic lesions was observed. It was found that the serum cholesterol level increasedwith the increased duration of cholesterol feeding and reached a peak at the 60th day,then decreased rapidly after feeding was stopped. However the LPO level didn't fall, in-stead it was increased continuously to a much higher level than that of the control. Theanti-oxidative enzymes SOD and GSH-Px showed compensatory increase at the early stageof high LPO level. There after, it was decreased and was kept in lower level than thatof the control. There were developed atherosclerotic lesions of various degree in aorta,pulmonary and coronary arteries. Even one month after the stop of cholesterol feeding,progressive changes, such as large amount of smooth muscle cell proliferation and inflam-matory cell infiltration were observed, and the lesions became much more severe thanbefore. These results suggested that the exess of LPO in the serum resulted in inhibitionof anti-oxidative enzyine activity Which might play an important role in the initiatingand developing of atherosclerosis.
