Effects of procainamide on ventricular fibrillation in a canine model of sudden coronary death
- VernacularTitle:普鲁卡因胺对犬冠心病心源性猝死实验模型的影响
- Author:
Zhibing GUO
;
Hongyu CAO
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Arrhythmia;
Ischemia;
Procainamide
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
A canine model of sudden coronary death was established by intimal sur-face anodal direct current stimulation of the left circumflex coronary artery (LCX)on 5-8 days after the left anterior descending coronary artery (LAD) infarction. TheLCX intimal injury and subsequent thrombus formation produced ECG ST segment chan-ges at 104?30 minutes (X?SD), followed by premature ventricular beats, ventriculartachycardia (VT), and ventricular fibrillation (VF) in all normal saline (NS) treated dogs(n=6), in procainamide (PA) treated dogs (n=6), ECG ST segment changes appearedat 110?40 minutes, followed by VT and VF in only one dog (P
