Pituitrin-induced myocardial ischemia——a model for screening oxy-radical scavenger in mice
- VernacularTitle:垂体后叶素性心肌缺血模型再探
- Author:
Weikang WU
;
Can HOU
- Publication Type:Journal Article
- Keywords:
Myocardium;
Ischemia;
Free radicals;
Lipid peroxides;
Superoxide dismutase
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
In this study we found that while pituitrin induced a significant decline of nutritional blood flow of myocardium in mice, oxygen free radical concentration andmalondialdehyde content significantly increased, and superoxide dismutase activity signifi-cantly declined in the ischemic myocardium. These results suggest that this pituitrin-inducedmyocardial ischemia in mice may serve as an easy-to-operate, cheap and in vivo model forscreening oxy-radical scavengers in the study of anti-ischemic myocardial injury.
