HLA-DR and DP antigens expression on human aortic smooth muscle cells in vitro
- VernacularTitle:培养的人主动脉平滑肌细胞异常表达HLA-DR、DP抗原
- Author:
Yanhong ZHU
;
Yongcai LU
- Publication Type:Journal Article
- Keywords:
Muscle,smooth,vascular;
Antigens;
Interferons;
Lymphocytes
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe whether human aortic smooth muscle cells (SMC) may expressHLA-DR and DP antigens, we used ?-IFN and lymphocytes conditioned media (LCM) to induce SMC in vitro. The results showed that ?-IFN increased HLA-DR and HLA-DP expression on SMC by 80% and 73%, and LCM did so by 74% and 70% respec-tively. HLA-DR and DP (11% and 7%) in both groups were significantly higher thanthat of the control group. These results suggested that activated T lymphocytes may in-crease HLA-DR and HLA-DP antigens expression on human SMC by secreating ?-IFN (orwith other cytokines), which may play certain important roles in atherogenesis.
