Alterations of brain glycosaminoglycans in hepatic encephalopathy in rats with thioacetamide-induced hepatic failure
- VernacularTitle:暴发性肝损伤肝性脑病大鼠脑糖胺多糖含量的变化
- Author:
Xianming CHEN
;
Ruiling XU
- Publication Type:Journal Article
- Keywords:
Thioacetamide;
Liver diseases;
Hepatic encephalopathy;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Changes of glycosaminoglycans in cerebrum, brainstem and cerebellum were measured in rats with hepatic encephalopathy induced by thioacetamide. It was foundthat the contents of glycosaminoglycans in brainstem and cerebrum were lowered markedlythan that of the normal control, but no significant difference of glycosaminoglycans werefound in cerebellum. The results suggested that the metabolism of glycosaminoglycans incerebrum and brainstem was disturbed when hepatic encephalopathy occured, and thatthe pathogenic mechanism of hepatic encephalopathy was related to the alterations of gly-cosaminoglycans in brain as a result of hepatic insufficiency.
