Effect of excitatory amino acids、Ca~(2+) on delayed neuronal death in hippocampus following transient forebrain ischemia in gerbils
- VernacularTitle:兴奋性氨基酸Ca~(2+)在短暂性脑缺血后海马DND发生机制中的作用
- Author:
Changqing XU
;
Linxin LI
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia,transient;
Hippocampus;
Neurons;
Necrosis;
Amino acid;
Calcium
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The contents of amino acids in dorsal hippocampus were measured at themoment of 10-min transient forebrain ischemia by using amino acid autoanalyser, delayedneuronal death (DND) model was established by bilateral carotid arteries occlusion for10-min followed by 7-day reperfusion. Effect of monosodium glutamate, ketamine on DNDin the hippocampus was examined by counting neuronal density in CA_1 sector. The Ca~(2+)content in dorsal hippocampus was measured, and the effect of ketamine on Ca~(2+) concen- tration was examined. The results showed that the contents of glutamate and aspartate indorsal hippocampus were increased significantly at the moment of 10-min transient fore-brain ischemia (P0.05). These results suggested that excitatory amino acids (EAA)and Ca~(2+) played an important role directly or indirectly in the development of DND inhippocampus following transient forebrain ischemia in gerbils; ca~(2+) over-load may be ancommon final pathway of neuronal death.
