Effects of captopril on free radical production and it's immune function
- VernacularTitle:卡托普利抗自由基作用及其免疫活性
- Author:
Xingwang WANG
;
Weirong GU
- Publication Type:Journal Article
- Keywords:
Captopril;
Superoxide dismutase;
Lipid peroxides;
Mice
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Captopril (CPT, 40, 80mg/kg, ig) enhanced serum superoxide dismutaseactivity, and suppressed luminal-dependent chemiluminescence of peritoneal macrophagesin mice. CPT (160mg/kg, ig) had a suppressive action on lipid peroxidation of mice. Theseresults suggested that CPT had antioxygen free radical effect or anti-lipid peroxidationeffects. CPT at 25 ?g/ml concentration suppressed ConA-induced prolifeation of mousesplenic T lymphocytes in vitro, which suggested that CPT had a suppressive effct on Tlymphocyte function.
