Factors affecting the alteration of hypoxic pulmonary vasoconstriction induced by cigarette smoking——animal species and the period of smoking
- VernacularTitle:吸烟引起肺血管反应性变化的影响因素——动物种属与吸烟时间
- Author:
Dixun WANG
;
Xianrong JIN
- Publication Type:Journal Article
- Keywords:
Smoking;
Vasoconstriction;
Animals;
Prostaglandins
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The alteration of hypoxic pulmonary vasoconstriction (HPV) induced bycigarette smoking was studied in Wistar rats, piglets and in humans. The percentage changeof pulmonary vascular resistance (△PVR%) and the amplitude of the systolic wave inimpedance pneumorheogram (△H%) were used to estimate the strength of HPV. It was observed that immediately after acute cigarette smoking, HPV in rats was in-creased (△PVR% from 55. 0?15. 6% to 102. 3?12. 4%), which was mainly mediated byleukotrienes (LTs); whereas HPV in piglets was decreased (△PVR% from 65.2?12. 5%to 55.9?9. 8%), which was mainly mediated by ? adrenergic receptors, and HPV inhumans was also increased (△H% from 20. 6? 2. 6% to 31. 1?4. 1%), in which prostag.landins and leukotrienes may play the role of mediators. However, after one-month ciga- rette smoking, the HPV of rats was significantly lowered (△PVR% 11. 4?1. 6%). Anincrease in vasodilative prostaglandins synthesis and a decrease in leukotrienes synthesismight haye contributed to this alteration of HPV.
